Family relationships are known to play a significant role in helping persons with mental health issues exit homelessness. This study aims to identify the independent quality of life factors that correlate with quality of family relationships. A cross-sectional design was used involving individuals enrolled in the At Home initiative for homeless persons with mental illness in five cities across Canada (N = 2,255). Linear regression analysis indicates that homeless persons’ mental health, community integration, general health status, number of symptoms, and recovery are playing a role in a better quality of life in the family and therefore can help to exit homelessness.