The ability of homeless and at-risk people to maintain good health is a recognized challenge in York Region, especially relating to social determinants of health and individuals’ physical ability to access health care resources. However, there are a very limited number of studies that document the specific health-related challenges of homeless and at-risk individuals in York Region. The health needs assessment findings documented in this report are an attempt to gain a broader understanding of the specific health needs of homeless and at-risk members of the York Region community. These findings are intended to guide and inform the development of specific health initiatives that will help to improve health and access to care among homeless and at-risk people in York Region.