While prior research establishes that youth who experience family problems are more likely to leave home before reaching adulthood, we know less regarding how peer victimization in the form of bullying may influence youths' likelihood of becoming runaways. Youth often run away from home to escape family conflict or abusive home environments. Mental illness, behavioral problems, and delinquent peers are also powerful forces predicting the likelihood of running away from home. Additionally, recent literature suggests that negative experiences at school may increase youths' decisions to leave home prematurely. In this article, I review literature that addresses who runs away from home, including variations by age, race/ethnicity, sexual orientation, gender, family structure, mental health, problem behaviors, and peer networks. I also suggest directions for future research, including an approach that considers how families and schools individually and collectively affect youths' likelihood of running away from home. Finally, I recommend a focus on bully victimization to better understand how victimization outside of the family affects the likelihood that youth will become runaways.