Whereas high risk groups such as asylum seekers are systematically screened for tuberculosis (TB) upon entry in Switzerland, this strategy does not apply to homeless despite a potentially elevated risk of TB. Geneva City Social Services operate shelters for homeless each winter. Shelters are underground facilities with 10 to 20-bed rooms. Every year, ≈ 1000 persons are accommodated. Geneva Health and Social Authorities implemented a collaborative project to screen for active TB in homeless. We aimed to assess 1/acceptability of the screening program and 2/prevalence of TB in this group.