Caring for vulnerable and marginalized populations is a central tenet of professional nursing, and of Christian service. Due to the scope and complexities of problems associated with homelessness, nurses may feel overwhelmed and ill-equipped to serve homeless individuals. Strategies for ending homelessness largely include resource-intensive, publically supported housing and comprehensive physical and mental health services. The role of spirituality in recovery from homelessness has not been widely examined. This article describes one homeless shelter's successful Christ-centered, comprehensive approach to helping individuals recover from homelessness. The integral role of the nurse in the multidisciplinary team and practical nursing interventions are described.